Loss of TGFβ Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance
نویسندگان
چکیده
منابع مشابه
Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance.
Antiestrogen resistance often develops with prolonged exposure to hormone therapies, including tamoxifen, and is a major problem in the treatment of breast cancer. Understanding the mechanisms involved in the development of antiestrogen resistance is an important step in the development of new targeted therapies. Two forms of antiestrogen resistance exist: de novo resistance and acquired resist...
متن کاملLoss of B-cell translocation gene 2 expression in estrogen receptor-positive breast cancer predicts tamoxifen resistance
B-cell translocation gene 2 (BTG2), a gene suppressed in a subset of aggressive breast cancer, is repressed by estrogen. BTG2 inhibits the expression of HER ligands and promotes AKT activation, which plays an essential role in the tamoxifen resistance of estrogen receptor (ER)-positive breast cancer. To determine if BTG2 expression modifies tamoxifen efficacy, a cohort of 60 patients treated wi...
متن کاملLoss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor α.
BACKGROUND Estrogen receptor (ER) α is a successful therapeutic target in breast cancer, but patients eventually develop resistance to antiestrogens such as tamoxifen. METHODS To identify genes whose expression was associated with the development of tamoxifen resistance and metastasis, we used microarrays to compare gene expression in four primary tumors from tamoxifen-treated patients whose ...
متن کاملEffect of cytotoxic drugs on estrogen receptor expression and response to tamoxifen in MCF-7 cells.
We have examined the effects of a 24-h exposure to clinically achievable concentrations of adriamycin, melphalan, 5-fluorouracil, and vincristine on the estrogen binding capacity of MCF-7 human breast cancer cells using a whole cell binding assay. Adriamycin (0.018 to 1.8 microM), melphalan (0.1 to 5 microM), 5-fluorouracil (0.077 to 15.4 microM), and vincristine (0.01 to 1 nM) reduce the estro...
متن کاملEffect of Cytotoxic Drugs on Estrogen Receptor Expression and Response to Tamoxifen in MCF-7 Cells1
We have examined the effects of a 24-h exposure to clinically achiev able concentrations of adriamycin, melphalan, 5-fluorouracil, and vincristine on the estrogen binding capacity of MCF-7 human breast cancer cells using a whole cell binding assay. Adriamycin (0.018 to 1.8 MM), melphalan (0.1 to 5 MM),5-fluorouracil (0.077 to 15.4 MM),and vincristine (0.01 to l nM) reduce the estrogen binding c...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2015
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-14-1583